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PROTAC TG2 degrader-2
😃Good
Catalog No. T79315
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2) with a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].
PROTAC TG2 degrader-2
PROTAC TG2 degrader-2
😃Good
Catalog No. T79315
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2) with a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2) with a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1]. |
| In vitro | PROTAC TG2 degrader-2 (Compound 7) (10 μΜ, up to 24 h) inhibits migration and invasion in wound healing assays, and reduces fibronectin adherence in OVCAR5 and SKOV3 cell lines. Additionally, at up to 10 μΜ for 6 h, it decreases transglutaminase 2 (TG2) levels in a concentration-dependent manner in both cell lines [1]. |
| Molecular Weight | 876.08 |
| Formula | C47H57N9O6S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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