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Pyrithione

Name: Pyrithione
Brand: TargetMol
SKU: T12593
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12593Cas No. 1121-30-8

Alias 1-hydroxyl-1H-pyridine-2-thione

Pyrithione (1-hydroxyl-1H-pyridine-2-thione) is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity.

Pyrithione

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Purity: 98.1%

Catalog No. T12593Alias 1-hydroxyl-1H-pyridine-2-thioneCas No. 1121-30-8

Pack Size	Price	Availability
5 mg	$41	In Stock
10 mg	$57	In Stock
25 mg	$87	In Stock
50 mg	$116	In Stock
100 mg	$157	In Stock

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Purity:98.1%

Resource Download

COA HPLC HNMR

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Product Introduction

Bioactivity

Description	Pyrithione (1-hydroxyl-1H-pyridine-2-thione) is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity.
Alias	1-hydroxyl-1H-pyridine-2-thione

Chemical Properties

Molecular Weight	127.16
Formula	C₅H₅NOS
Cas No.	1121-30-8
Smiles	S=C1N(O)C=CC=C1
Relative Density.	1.255 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 120 mg/mL (943.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.8641 mL	39.3205 mL	78.6411 mL	393.2054 mL
5 mM	1.5728 mL	7.8641 mL	15.7282 mL	78.6411 mL
10 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
20 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
50 mM	0.1573 mL	0.7864 mL	1.5728 mL	7.8641 mL
100 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PyrithioneInhibitorinhibitFungalBacterial