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QCA570
😃Good
Catalog No. T16701Cas No. 2207569-08-0
QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).
QCA570
😃Good
Catalog No. T16701Cas No. 2207569-08-0
QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | |
| 100 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein). |
| Targets&IC50 | BRD4 BD1:10 nM |
| In vitro | QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines (IC50: 8.3, 62, and 32 pM, respectively). QCA570 is an extremely effective and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. [1]. |
| Molecular Weight | 695.79 |
| Formula | C39H33N7O4S |
| Cas No. | 2207569-08-0 |
| Relative Density. | 1.40 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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