Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

RIG012

🥰Excellent
Catalog No. T73486Cas No. 2642218-43-5

RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM (measured by NADH-coupled ATPase), and it inhibits the expression of IFN-β and ISG hRsad2.

RIG012

RIG012

🥰Excellent
Purity: 99.53%
Catalog No. T73486Cas No. 2642218-43-5
RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM (measured by NADH-coupled ATPase), and it inhibits the expression of IFN-β and ISG hRsad2.
Pack SizePriceAvailabilityQuantity
1 mg$116 In Stock
5 mg$289 In Stock
10 mg$463 In Stock
25 mg$763 In Stock
50 mg$987 In Stock
100 mg$1,380 In Stock
500 mg$2,780 In Stock
1 mL x 10 mM (in DMSO)$318 In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "RIG012"

Select Batch
Purity:99.53%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM (measured by NADH-coupled ATPase), and it inhibits the expression of IFN-β and ISG hRsad2.
Targets&IC50
RIG-I:0.71 μM
In vitro
RIG012 (1, 1.25, 1.5, 2, 2.5, 3, 4 μM) has potent dose-dependent inhibition of RIG-I signaling in HEK293T cells co-transfected with expression plasmids and reporter plasmids.[1]
RIG012 (1.25, 2.25, 4.5, 9, 18 μM) has potent dose-dependent inhibition of IFN-β and ISG hRsad2 expression in A549 cells.[1]
RIG012 contains a strong chromophore that absorbs in the visible range (λmax of 470 nm). Upon binding to RIG-I, the 470 nm absorption band of RIG012 undergoes a significant hyperchromic shift toward higher intensity values.[1]
Chemical Properties
Molecular Weight359.42
FormulaC23H21NO3
Cas No.2642218-43-5
SmilesC(C)C1(CC)C=2C(C=3C(C(=O)C2OCC4=CC=CC=C4)=CC=CC3)=NC1=O
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 7 mg/mL (19.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7823 mL13.9113 mL27.8226 mL139.1130 mL
5 mM0.5565 mL2.7823 mL5.5645 mL27.8226 mL
10 mM0.2782 mL1.3911 mL2.7823 mL13.9113 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy RIG012 | purchase RIG012 | RIG012 cost | order RIG012 | RIG012 chemical structure | RIG012 in vitro | RIG012 formula | RIG012 molecular weight