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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $397 | In Stock | |
25 mg | $652 | In Stock | |
50 mg | $913 | In Stock | |
100 mg | $1,230 | In Stock | |
500 mg | $2,460 | In Stock |
Description | RO5166017 is an orally active, potent and selective trace amine-associated receptor 1 (TAAR1) agonist for the study of conditioned taste aversion frontal nerve disorders. |
In vitro | RO5166017 exhibits high affinity and potent functional activity against mouse/rat/cynomolgus/human TAAR1 stably expressed in HEK293 cells and demonstrates high selectivity relative to other targets[2]. |
In vivo | RO5166017 prevents stress-induced hyperthermia and blocks dopamine-dependent hyperlocomotion in cocaine-treated and dopamine transporter knockout mice, as well as NMDA antagonist-induced hyperactivity[2].Administered orally at doses of 0.01-1 mg/kg, RO5166017 dose-dependently prevents stress-induced hyperthermia in NMRI mice. At doses of 0.1-0.3 mg/kg, RO5166017 exhibits TAAR1-mediated anxiolytic-like properties[2].RO5166017 prevents cocaine-induced hyperlocomotion and inhibits cocaine-induced stereotypies in WT mice, similar to olanzapine, an effect that disappears in Taar1 mice[1].Activation of TAAR1 by RO5166017 increases glucose-dependent insulin secretion in INS1E cells and human islets, and elevates plasma levels of peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) in mice[1]. Chronic treatment of diet-induced obese (DIO) mice with RO5166017 reduces food intake and body weight[1]. |
Alias | RO 5166017, RO-5166017 |
Molecular Weight | 219.28 |
Formula | C12H17N3O |
Cas No. | 1048346-74-2 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (91.21 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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