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Semustine

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Catalog No. T16871Cas No. 13909-09-6

Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.

Semustine

Semustine

🥰Excellent
Purity: 99%
Catalog No. T16871Cas No. 13909-09-6
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.
Pack SizePriceAvailabilityQuantity
1 mg$138In Stock
5 mg$397In Stock
10 mg$589In Stock
25 mg$945In Stock
50 mg$1,280In Stock
100 mg$1,730In Stock
500 mg$3,460In Stock
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Purity:99%
ee:99.28%
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Product Introduction

Bioactivity
Description
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.
In vivo
Semustine (Me-CCNU) (150 mg×m(-2)×d(-1) once; oral; repeated every 28 days) treatment periods were within 2 - 6 months; follow-up period was 6 months. PFS at 6 months was 55.88% in the Me-CCNU group (P < 0.05). Overall survival rates at the end of the follow-up period were 97.30% in the Me-CCNU group (P > 0.05). Adverse events rates of Me-CCNU was 45.15% (P < 0.05).[2]
Chemical Properties
Molecular Weight247.72
FormulaC10H18ClN3O2
Cas No.13909-09-6
SmilesN(C(N(CCCl)N=O)=O)C1CCC(C)CC1
Relative Density.1.31 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 45.0 mg/mL (181.7 mM), Sonication is recommended.
DMSO: 90.0 mg/mL (363.3 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.0368 mL20.1841 mL40.3682 mL201.8408 mL
5 mM0.8074 mL4.0368 mL8.0736 mL40.3682 mL
10 mM0.4037 mL2.0184 mL4.0368 mL20.1841 mL
20 mM0.2018 mL1.0092 mL2.0184 mL10.0920 mL
50 mM0.0807 mL0.4037 mL0.8074 mL4.0368 mL
100 mM0.0404 mL0.2018 mL0.4037 mL2.0184 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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