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Senazodan hydrochloride

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Catalog No. T28752Cas No. 98326-33-1
Alias Senazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HCl

Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.

Senazodan hydrochloride

Senazodan hydrochloride

🥰Excellent
Purity: 99.93%
Catalog No. T28752Alias Senazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HClCas No. 98326-33-1
Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.
Pack SizePriceAvailabilityQuantity
1 mg$100 In Stock
5 mg$247 In Stock
10 mg$396 In Stock
25 mg$787 In Stock
50 mg$1,180 In Stock
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Purity:99.93%
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Product Introduction

Bioactivity
Description
Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.
In vitro
Senazodan hydrochloride appears to modulate actin-myosin cross-bridge dynamics and promote myosin ATPase activity [1].
Senazodan hydrochloride increases tonogenesis in a concentration-dependent manner while enhancing the binding capacity of calcium ions (Ca²⁺) to myofilaments as well as purified cardiac troponin C. The binding capacity of calcium ions to myofilaments is also enhanced by Senazodan hydrochloride. In addition, cenazolone hydrochloride improves contractile properties of guinea pig papillary muscle by inhibiting phosphodiesterase III (PDE III) [2].
Senazodan hydrochloride attenuated the contractile response induced by norepinephrine (NE) on the superior mesenteric artery (SMA) after hemorrhagic shock over the concentration range of 0.1 nM to 0.1 mM, which was significantly reduced compared to normal controls. 0.01 mM Senazodan hydrochloride pretreatment was able to inhibit the contraction of angiotensin II (Ang II) in guinea pigs. The effect of angiotensin II (Ang II) was significantly shifted to the right of the calcium concentration-response curve, which was more prominent in the Ang II group compared to the Ang II group alone. [3]
In vivo
0.1 to 2.0 mg/kg Senazodan hydrochloride infused through a femoral vein catheter reduces the antihypertensive effect of norepinephrine (NE). [3]
Intravenous infusion of 0.1 mg/kg Senazodan hydrochloride significantly elevated left ventricular systolic pressure (LVSP), myocardial contractility (IP), myocardial contractility (MC), and left ventricular output (Lo) without significant changes in heart rate. Meanwhile, left ventricular end-diastolic pressure (LVEDP) was significantly decreased. [4]
AliasSenazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HCl
Chemical Properties
Molecular Weight302.76
FormulaC15H15ClN4O
Cas No.98326-33-1
SmilesCl.O=C1NN=C(C=2C=CC(=CC2)NC=3C=CN=CC3)CC1
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50.00 mg/mL (165.15 mM), Sonication is recommended.
H2O: 20.00 mg/mL (66.06 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3029 mL16.5147 mL33.0295 mL165.1473 mL
5 mM0.6606 mL3.3029 mL6.6059 mL33.0295 mL
10 mM0.3303 mL1.6515 mL3.3029 mL16.5147 mL
20 mM0.1651 mL0.8257 mL1.6515 mL8.2574 mL
50 mM0.0661 mL0.3303 mL0.6606 mL3.3029 mL
DMSO
1mg5mg10mg50mg
100 mM0.0330 mL0.1651 mL0.3303 mL1.6515 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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