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Sphinganine 1-phosphate
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Catalog No. T39401Cas No. 19794-97-9
Alias Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphate
Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.
Sphinganine 1-phosphate
😃Good
Catalog No. T39401Alias Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphateCas No. 19794-97-9
Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $223 | 35 days | |
| 1 mg | $395 | 35 days | |
| 5 mg | $1,430 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy. |
| In vitro | Sphinganine 1-phosphate (S1P) (1 μM) phosphorylates ERK MAPK, AKT and HSP27 and induces HSP27 in human renal endothelial cells. [2] |
| In vivo | Methods: Male C57BL/6 mice were treated with Sphinganine 1-phosphate (0.1 mg/kg, 0.1 mg/kg intravenously immediately before reperfusion, 0.2 mg/kg subcutaneously 2 hours after reperfusion) and the changes in plasma levels of alanine aminotransferase (ALT) and creatinine (CR) were analyzed. Results: The plasma levels of alanine aminotransferase (ALT) and creatinine (CR) were 80±6 U/L and 0.46±0.05 mg/dl, respectively; in mice treated with Sphinganine 1-phosphate (0.1 mg/kg), the increase in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) was significantly suppressed after 24 hours. [2] |
| Alias | Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphate |
| Molecular Weight | 381.49 |
| Formula | C18H40NO5P |
| Cas No. | 19794-97-9 |
| Smiles | [C@@H]([C@@H](CCCCCCCCCCCCCCC)O)(COP(=O)(O)O)N |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | 0.3 M NaOH: 1 mg/mL (2.62 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
0.3 M NaOH
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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