Sphinganine 1-phosphate, also known as D-erythro-Dihydrosphingosine 1-phosphate, is a polar sphingolipid metabolite. It plays a crucial role in regulating various cellular processes including cell migration, differentiation, survival, and complex physiological processes.

Sphinganine 1-phosphate (S1P) is a critical signaling molecule involved in stress responses, cancer progression, angiogenesis, lymphocyte trafficking, and the regulation of cell metabolism. It activates specific endothelial differentiation gene (EDG) family G-protein coupled receptors on cell surfaces. S1P supports skeletal muscle differentiation and regeneration[1] and influences cancer by mediating inflammation, neovascularization, and cell proliferation and survival[1]. At a 1μM concentration, S1P has been shown to phosphorylate ERK MAPK, Akt, and HSP27, and induce HSP27 expression in human renal endothelial cells in experimental studies[2]. Using a Cell Viability Assay, the compound at 1μM concentration increased HSP27 mRNA expression and phosphorylated ERK MAPK and AKT in a time-dependent manner[2], demonstrating its significant role in cellular functions.

Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. It provides renal and hepatic protection post-liver ischemia and reperfusion (IR) injury in mice by selectively activating S1P1 receptors and pertussis toxin-sensitive G-proteins, leading to ERK and Akt activation. Administered at 0.1 mg/kg i.v. immediately before reperfusion, and 0.2 mg/kg s.c. 2 hours post-reperfusion, it protects against hepatic and renal injury in male C57BL/6 mice (20-25 g)[2]. Results show significant suppression in ALT and Creatinine levels, with plasma ALT at 80±6 U/L and Cr at 0.46±0.05 mg/dL, compared to increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) 24 hours post-reperfusion in treated mice.