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SRI-42127

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Purity:99.66%

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COA HPLC HNMR

SRI-42127

Catalog No. T73286Cas No. 2727872-68-4

SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.

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Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$139	In Stock
10 mg	$255	In Stock
25 mg	$513	In Stock
50 mg	$728	In Stock
100 mg	$985	In Stock
500 mg	$1,970	In Stock

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Product Introduction

Bioactivity

Description	SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
In vitro	SRI-42127 (0.05-1 μM; 24 h) inhibits HuR translocation in LPS-activated glial cells in vitro, significantly reducing the production of pro-inflammatory mediators such as IL1β, IL-6, TNF-α, iNOS, CXCL1, and CCL2[1].
In vivo	SRI-42127 (15 mg/kg; intraperitoneal injection; single dose) inhibits in vivo microglial activation and reduces neutrophil and monocyte recruitment/chemotaxis[1].

Chemical Properties

Molecular Weight	348.4
Formula	C19H20N6O
Cas No.	2727872-68-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (86.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8703 mL	14.3513 mL	28.7026 mL	143.5132 mL
5 mM	0.5741 mL	2.8703 mL	5.7405 mL	28.7026 mL
10 mM	0.2870 mL	1.4351 mL	2.8703 mL	14.3513 mL
20 mM	0.1435 mL	0.7176 mL	1.4351 mL	7.1757 mL
50 mM	0.0574 mL	0.2870 mL	0.5741 mL	2.8703 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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SRI-42127

SRI-42127

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