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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock | |
5 mg | $139 | In Stock | |
10 mg | $255 | In Stock | |
25 mg | $513 | In Stock | |
50 mg | $728 | In Stock | |
100 mg | $985 | In Stock | |
500 mg | $1,970 | In Stock |
Description | SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response. |
In vitro | SRI-42127 (0.05-1 μM; 24 h) inhibits HuR translocation in LPS-activated glial cells in vitro, significantly reducing the production of pro-inflammatory mediators such as IL1β, IL-6, TNF-α, iNOS, CXCL1, and CCL2[1]. |
In vivo | SRI-42127 (15 mg/kg; intraperitoneal injection; single dose) inhibits in vivo microglial activation and reduces neutrophil and monocyte recruitment/chemotaxis[1]. |
Molecular Weight | 348.4 |
Formula | C19H20N6O |
Cas No. | 2727872-68-4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (86.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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