Shopping Cart

Remove All

Your shopping cart is currently empty

CMLD-2

Select Batch

Purity:99.16%

Resource Download

COA HPLC HNMR

CMLD-2

Catalog No. T36493Cas No. 958843-91-9

CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 μM ; 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 μM ; 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 μM ; 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 μM ; 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 μM ; 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$247	In Stock
10 mg	$413	In Stock
25 mg	$676	In Stock
50 mg	$943	In Stock
100 mg	$1,270	In Stock
500 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "CMLD-2"

Product Introduction

Bioactivity

Description	CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 μM ; 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 μM ; 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 μM ; 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 μM ; 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 μM ; 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.
In vitro	CMLD-2 (35 μM ; 72 h) impairs directional migration ability and significantly diminishes MAD2 mRNA levels in SW1736, 8505C, BCPAP, and K1 cells.[2] CMLD-2 (20-30 μM ; 24-48 h) triggers caspase activation and induces apoptosis in H1299 and A549 cells.[2] CMLD-2 (30 μM ; 24-48 h) causes G1 cell cycle arrest and disrupts mitochondrial function in H1299 and A549 cells.[2] CMLD-2 (30 μM ; 24-48 h) decreases the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.[2] CMLD-2 (1-75 μM ; 24-72 h) suppresses thyroid cancer cell viability.[3] CMLD-2 (0.1-10 μM) reduced the activity of mouse and human sensory neurons.[5]
In vivo	CMLD-2 (0.3 μg, 1 μg, 3 μg ; i.pl.) attenuated NGF (left), and IL-6 (right) induced mechanical hypersensitivity during the acute and priming phase in male mice.[5]

Chemical Properties

Molecular Weight	513.58
Formula	C31H31NO6
Cas No.	958843-91-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (126.56 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9471 mL	9.7356 mL	19.4712 mL	97.3558 mL
5 mM	0.3894 mL	1.9471 mL	3.8942 mL	19.4712 mL
10 mM	0.1947 mL	0.9736 mL	1.9471 mL	9.7356 mL
20 mM	0.0974 mL	0.4868 mL	0.9736 mL	4.8678 mL
50 mM	0.0389 mL	0.1947 mL	0.3894 mL	1.9471 mL
100 mM	0.0195 mL	0.0974 mL	0.1947 mL	0.9736 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc