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SUN 1334H
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Catalog No. T13040Cas No. 607736-84-5
SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM.
SUN 1334H
😃Good
Catalog No. T13040Cas No. 607736-84-5
SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | Inquiry | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM. |
| Targets&IC50 | H1 receptor:ki： 9.7 nM |
| In vitro | In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2]. |
| In vivo | In beagle dogs and in ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm for 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H significantly reduces passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effect models, SUN-1334H, desloratadine, and fexofenadine show no significant effects [2]. |
| Molecular Weight | 489.38 |
| Formula | C23H28Cl2F2N2O3 |
| Cas No. | 607736-84-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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