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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 6-8 weeks | |
50 mg | Inquiry | 6-8 weeks | |
100 mg | Inquiry | 6-8 weeks |
Description | SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM). |
In vitro | In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2]. |
In vivo | In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2]. |
Molecular Weight | 489.38 |
Formula | C23H28Cl2F2N2O3 |
Cas No. | 607736-84-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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