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Swinholide A
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Catalog No. T35782Cas No. 95927-67-6
Alias MK-7684
Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.
Swinholide A
😃Good
Catalog No. T35782Alias MK-7684Cas No. 95927-67-6
Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg | $290 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells. |
| In vitro | First isolated from the Okinawan marine sponge Theonella swinhoei, Swinholide A dimerizes actin[1]. Isolated from the marine sponge Theonella swinhoei, Swinholide A is highly cytotoxic to a variety of cancer cell lines[2]. Disrupting the actin cytoskeleton of cells grown in culture, Swinholide A sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers, with a binding stoichiometry of one Swinholide A molecule per actin dimer. Additionally, it rapidly severs F-actin in vitro with high cooperativity[2]. |
| Alias | MK-7684 |
| Molecular Weight | 1389.87 |
| Formula | C78H132O20 |
| Cas No. | 95927-67-6 |
| Smiles | [H][C@]12CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]3C[C@@H](C[C@H](C)O3)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C[C@]3([H])CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]4C[C@@H](C[C@H](C)O4)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C1)OC)O3)OC)O2 |c:3,53| |
| Relative Density. | 1.15 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Methanol: Soluble DMSO: Soluble Ethanol: Soluble |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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