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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 μg | $290 | 35 days |
Description | Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells. |
In vitro | First isolated from the Okinawan marine sponge Theonella swinhoei, Swinholide A dimerizes actin[1]. Isolated from the marine sponge Theonella swinhoei, Swinholide A is highly cytotoxic to a variety of cancer cell lines[2]. Disrupting the actin cytoskeleton of cells grown in culture, Swinholide A sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers, with a binding stoichiometry of one Swinholide A molecule per actin dimer. Additionally, it rapidly severs F-actin in vitro with high cooperativity[2]. |
Alias | MK-7684 |
Molecular Weight | 1389.87 |
Formula | C78H132O20 |
Cas No. | 95927-67-6 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Methanol: Soluble DMSO: Soluble Ethanol: Soluble |
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