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TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

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Catalog No. TP2157L
Alias TDE TFA, TAT-DEF-Elk-1 TFA

TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)
Other Forms of TAT-DEF-Elk-1 TFA (1220751-16-5 free base):

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

😃Good
Catalog No. TP2157LAlias TDE TFA, TAT-DEF-Elk-1 TFA
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity
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Product Introduction

Bioactivity
Description
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act
Targets&IC50
ELK1:
In vitro
Elk-1 phosphorylation on Ser383/389 has a dual function and triggers both Elk-1 nuclear translocation and SRE-dependent gene expression. TAT-DEF-Elk-1 (5 μM; 2 hours) treatment shows significant inhibition of c-Fos, Zif268, and JunB, but has no effects on c-Jun expression. TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation and does not interfere with ERK, MSK-1, or CREB phosphorylation [1].
In vivo
TAT-DEF-Elk-1 (i.p.; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the antidepressant desipramine and fluoxetine [2].
AliasTDE TFA, TAT-DEF-Elk-1 TFA
Chemical Properties
Molecular Weight3675.09
FormulaC157H260N57F3O42
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

TAT DEF Elk 1 TFA (1220751 16 5 free base)1220751-16-5 free baseTATDEFElk1 TFA (1220751165 free base)1220751-16-5
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