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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $125 | In Stock | |
5 mg | $373 | In Stock | |
10 mg | $623 | In Stock |
Description | TAT-DEF-Elk-1 acetate is a cell-penetrating peptide inhibitor of ERK1/2 kinase phosphorylated Elk-1 with antitumor and antidepressant activity.TAT-DEF-Elk-1 acetate inhibits the phosphorylation of Elk-1, inhibits Elk-1 nuclear TAT-DEF-Elk-1 acetate inhibits Elk-1 phosphorylation and Elk-1 nuclear translocation, and can be used to study depression. |
In vitro | Phosphorylation of Elk-1 on Ser383/389 has dual functions, triggering Elk-1 nuclear translocation and SRE-dependent gene expression; TAT-DEF-Elk-1 (5 μM; 2 h) treatment significantly inhibited c - Fos, Zif268, and JunB, but has no effect on c-Jun expression; TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation without interfering with ERK , MSK-1 or CREB phosphorylation. [1] |
In vivo | TAT-DEF-Elk-1 (ip; 1 mg/kg; daily; 14 days) reflected antidepressant efficacy in mice, reducing immobility similar to the reference antidepressants fluoxetine and desipramine (DMI).[2] |
Alias | TAT-DEF-Elk-1 acetate(1220751-16-5 Free base), TED acetate |
Molecular Weight | 3621.19 |
Formula | C157H263N57O42 |
Cas No. |
Storage | store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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