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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $700 | 8-10 weeks | |
5 mg | $1,800 | 8-10 weeks |
Description | Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers. |
In vivo | In a rat model of postoperative pain, Thioflosulide (L-745337) coadministered intrathecally (40-80 μg) with intrathecal morphine (0.5 nmol) increases withdrawal thresholds in a dose-dependent manner. Adding 80 μg of Thioflosulide (L-745337) to 1 nmol of morphine produces a greater antiallodynic effect than morphine at twice the dose. When combined with intrathecal morphine, Thioflosulide (L-745337) administered subcutaneously (0-30 mg/kg) results in the same antiallodynic response as morphine alone[1].Thioflosulide (L-745337) also exhibits anti-inflammatory activity, with an effective dose of 0.4 mg/kg and a maximal anti-inflammation dose of 5 mg/kg in arthritic rats[3]. |
Alias | L-745337 |
Molecular Weight | 369.41 |
Formula | C16H13F2NO3S2 |
Cas No. | 158205-05-1 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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