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TP0586532

Name: TP0586532
Brand: TargetMol
SKU: T9318
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T9318Cas No. 2427584-96-9

TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk.

TP0586532

🥰Excellent

Catalog No. T9318Cas No. 2427584-96-9

TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk.

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk.
Targets&IC50	LpxC:0.101 μM
In vitro	TP0586532 is an inhibitor of UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with an IC50 of 0.101 μM[1].

Chemical Properties

Molecular Weight	460.52
Formula	C₂₆H₂₈N₄O₄
Cas No.	2427584-96-9
Smiles	[H][C@@]12CN(CCCC(O)=O)C[C@]1([H])[C@H]2C#Cc1ccc(cc1)-c1cc(Cn2ccnc2[C@H](C)O)no1
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (108.57 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1715 mL	10.8573 mL	21.7146 mL	108.5729 mL
5 mM	0.4343 mL	2.1715 mL	4.3429 mL	21.7146 mL
10 mM	0.2171 mL	1.0857 mL	2.1715 mL	10.8573 mL
20 mM	0.1086 mL	0.5429 mL	1.0857 mL	5.4286 mL
50 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1715 mL
100 mM	0.0217 mL	0.1086 mL	0.2171 mL	1.0857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TP-0586532TP0586532TP 0586532strainsriskresistantpneumoniaenon-hydroxamateLpxClowInhibitorinhibiteffectivecardiovascularBacterial