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Trequinsin hydrochloride

Catalog No. T23476Cas No. 78416-81-6
Alias HL 725

Trequinsin hydrochloride (HL 725) is a potent phosphodiesterase (PDE) inhibitor and inhibitor of platelet aggregation, and is a novel antihypertensive vasodilator for the study of cardiovascular disease.

Trequinsin hydrochloride

Trequinsin hydrochloride

Purity: 99.95%
Catalog No. T23476Alias HL 725Cas No. 78416-81-6
Trequinsin hydrochloride (HL 725) is a potent phosphodiesterase (PDE) inhibitor and inhibitor of platelet aggregation, and is a novel antihypertensive vasodilator for the study of cardiovascular disease.
Pack SizePriceAvailabilityQuantity
2 mg$108In Stock
25 mg$6326-8 weeks
50 mg$8226-8 weeks
100 mg$1,3606-8 weeks
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Trequinsin hydrochloride (HL 725) is a potent phosphodiesterase (PDE) inhibitor and inhibitor of platelet aggregation, and is a novel antihypertensive vasodilator for the study of cardiovascular disease.
Targets&IC50
platelet cAMP phosphodiesterase (PDE):0.25 nM
In vitro
In addition to its cardioprotective and antihypertensive effects, Trequinsin hydrochloride exhibits significant antiplatelet activity.Trequinsin hydrochloride is a potent inhibitor of platelet cAMP phosphodiesterase (PDE) with an IC50 of 0.25 nM. [1]
In addition, Trequinsin hydrochloride is a potent calcium agonist. [3]
AliasHL 725
Chemical Properties
Molecular Weight441.95
FormulaC24H28ClN3O3
Cas No.78416-81-6
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 40 mg/mL (90.51 mM), Sonication is recommended.
DMSO: 50 mg/mL (113.13 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.2627 mL11.3135 mL22.6270 mL113.1350 mL
5 mM0.4525 mL2.2627 mL4.5254 mL22.6270 mL
10 mM0.2263 mL1.1313 mL2.2627 mL11.3135 mL
20 mM0.1131 mL0.5657 mL1.1313 mL5.6567 mL
50 mM0.0453 mL0.2263 mL0.4525 mL2.2627 mL
DMSO
1mg5mg10mg50mg
100 mM0.0226 mL0.1131 mL0.2263 mL1.1313 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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