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Urocortin, rat TFA (171543-83-2 free base)
Catalog No. TP2159
Alias Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA
Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
Urocortin, rat TFA (171543-83-2 free base)
Urocortin, rat TFA (171543-83-2 free base)
Catalog No. TP2159Alias Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA
Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
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Product Introduction
Bioactivity
Chemical Properties
| Description | Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1). |
| Targets&IC50 | CRF1 (human):ki： 13 nM , CRF2α (rat):1.5 nM (ki), CRF2β (mouse):0.97 nM (ki) |
| In vitro | In stably transfected Chinese hamster ovary cells, Urocortin, rat induces cAMP generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively [2]. |
| In vivo | Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat (i.c.v.). It has the potential of inducing anxiogenic behavior [3]. |
| Alias | Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA |
| Molecular Weight | 4821.28 |
| Formula | C208H339N62F3O66 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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