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Veliflapon
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
Catalog No. T13295Cas No. 128253-31-6
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Veliflapon
Catalog No. T13295Alias DG-031, BAY X 1005Cas No. 128253-31-6
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $766 | 6-8 weeks | |
| 50 mg | $995 | 6-8 weeks | |
| 100 mg | $1,690 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4. |
| In vitro | Veliflapon inhibits the synthesis of LTB4 in A23187-stimulated leukocytes from rats, mice and humans with IC50s of 0.026, 0.039 and 0.22 μM, respectively as well as the formation of LTC4 with IC50 of 0.021 μM in mouse peritoneal macrophages stimulated with opsonized zymosan[3]. |
| In vivo | Atherogenesis inhibited by Veliflapon (DG-031; diet; 18.8 mg/kg/day for 16 weeks ). In the arachidonic acid-induced mouse ear inflammation test,Veliflapon after topical (18 μg/ear) and oral (48.7 mg/kg) administration has antiedematous effects [4]. Veliflapon is potent (11.8 and 6.7 mg/kg p.o. at 1 and 5 hours, respectively) and has a long duration of action (ED40 of 16 hours, 70 mg/kg p.o.) in the rat whole blood ex vivo leukotriene B4 inhibition assay[4]. |
| Alias | DG-031, BAY X 1005 |
| Molecular Weight | 361.43 |
| Formula | C23H23NO3 |
| Cas No. | 128253-31-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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