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Z-Asp-CH2-DCB

🥰Excellent
Catalog No. T13378Cas No. 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

Z-Asp-CH2-DCB

Z-Asp-CH2-DCB

🥰Excellent
Purity: 99.08%
Catalog No. T13378Cas No. 153088-73-4
Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.
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Purity:99.08%
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COA HPLC HNMR
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Product Introduction

Bioactivity
Description
Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.
In vitro
Z-Asp-CH2-DCB (10-100 μM) dose-dependently inhibits the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng) PBMC, and suppresses the chemokines MCP-1, MIP-1α, and MIP-1β[1]. Additionally, Z-Asp-CH2-DCB reduces IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β production in TSST-1-activated PBMC to 10%, 36%, 25%, 10%, 11%, 25%, and 30%, respectively[1].
In vivo
SU5416-induced septal cell apoptosis prevented byZ-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks)[1].
Chemical Properties
Molecular Weight454.26
FormulaC20H17Cl2NO7
Cas No.153088-73-4
SmilesOC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)COC(=O)c1c(Cl)cccc1Cl
Relative Density.1.440 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95.4 mg/mL (210 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2014 mL11.0069 mL22.0138 mL110.0691 mL
5 mM0.4403 mL2.2014 mL4.4028 mL22.0138 mL
10 mM0.2201 mL1.1007 mL2.2014 mL11.0069 mL
20 mM0.1101 mL0.5503 mL1.1007 mL5.5035 mL
50 mM0.0440 mL0.2201 mL0.4403 mL2.2014 mL
100 mM0.0220 mL0.1101 mL0.2201 mL1.1007 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Z-Asp-CH2-DCBZ-Asp-CH-2-DCBZAspCH2DCBZ Asp CH2 DCB
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