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4′-DTMP

Catalog No. T78238Cas No. 21253-58-7
Alias 4-Demethyltrimethoprim

4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.

4′-DTMP

4′-DTMP

Catalog No. T78238Alias 4-DemethyltrimethoprimCas No. 21253-58-7
4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.
Pack SizePriceAvailabilityQuantity
10 mg$308-10 weeks
25 mg$418-10 weeks
50 mg$678-10 weeks
100 mg$988-10 weeks
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Product Introduction

Bioactivity
Description
4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.
Targets&IC50
L28R:34.3 nM, WT:5.1 nM (Ki)
Alias4-Demethyltrimethoprim
Chemical Properties
Molecular Weight276.29
FormulaC13H16N4O3
Cas No.21253-58-7
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (108.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6194 mL18.0969 mL36.1939 mL180.9693 mL
5 mM0.7239 mL3.6194 mL7.2388 mL36.1939 mL
10 mM0.3619 mL1.8097 mL3.6194 mL18.0969 mL
20 mM0.1810 mL0.9048 mL1.8097 mL9.0485 mL
50 mM0.0724 mL0.3619 mL0.7239 mL3.6194 mL
100 mM0.0362 mL0.1810 mL0.3619 mL1.8097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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