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Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated

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Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPK-00845

Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.

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Pack Size	Price	Availability
100 μg	$814	7-10 days
500 μg	$3,250	7-10 days
1 mg	$5,440	7-10 days

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Biological Description

Biological Information	Immobilized Biotinylated Human Siglec-3, His Tag at 0.5μg/ml (100μl/Well) on streptavidin (5μg/ml) precoated plate. Dose response curve for Anti-Siglec-3 Antibody, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA.
Description	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	P20138-1
Synonyms	Siglec3,p67,FLJ00391,Siglec-3,gp67,CD33,CD33 molecule
Construction	Asp18-His259
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Molecular Weight	29.6 kDa (predicted). Due to glycosylation, the protein migrates to 48-58 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in 50m MES, 500 mM NaCl, 200 mM L-arginine (pH 7.4).
Stability & Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs.