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Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μg | $383 | 7-10 days | |
100 μg | $913 | 7-10 days |
Biological Information | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
Description | TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P37173. |
Species | Human |
Expression System | HEK293 Cells |
Tag | His, hFc |
Accession Number | P37173 |
Synonyms | transforming growth factor, β receptor II,transforming growth factor, beta receptor II (70/80kDa),TGFβ-RII,TGFR-2,TGFbeta-RII,TAAD2,RIIC,MFS2,LDS2B,LDS2,LDS1B,FAA3,AAT3 |
Construction | A DNA sequence encoding the extracellular domain (Met1-Asp159) of human TGFB receptor 2 (NP_003233.4) was expressed with the fused C-terminal His-tagged Fc region of human IgG1 at the C-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Thr 23 |
Protein Purity | > 95 % as determined by SDS-PAGE. |
Molecular Weight | 43.4 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity. |
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