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(±)14(15)-EpETE

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Catalog No. T37234Cas No. 131339-24-7

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.

(±)14(15)-EpETE

(±)14(15)-EpETE

😃Good
Catalog No. T37234Cas No. 131339-24-7
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
Pack SizePriceAvailabilityQuantity
25 μg$120 35 days
50 μg$223 35 days
100 μg$420 35 days
500 μg$1,840 35 days
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Concentration:0.1 mg/mL
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Product Introduction

Bioactivity
Description
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
Chemical Properties
Molecular Weight318.457
FormulaC20H30O3
Cas No.131339-24-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (157.01 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (3.14 mM), Sonication is recommended.
Ethanol: 50 mg/mL (157.01 mM), Sonication is recommended.
DMF: 50 mg/mL (157.01 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/Ethanol/DMF
1mg5mg10mg50mg
1 mM3.1401 mL15.7007 mL31.4014 mL157.0071 mL
DMSO/Ethanol/DMF
1mg5mg10mg50mg
5 mM0.6280 mL3.1401 mL6.2803 mL31.4014 mL
10 mM0.3140 mL1.5701 mL3.1401 mL15.7007 mL
20 mM0.1570 mL0.7850 mL1.5701 mL7.8504 mL
50 mM0.0628 mL0.3140 mL0.6280 mL3.1401 mL
100 mM0.0314 mL0.1570 mL0.3140 mL1.5701 mL

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