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Lyoniresinol
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Catalog No. TN4469Cas No. 14464-90-5
Lyoniresinol, a lignan isolated from Tarenna attenuata, exhibits free radical scavenging activity (IC50 of 82.4 μM) and DPPH antioxidant activity, demonstrating anti-melanogenic properties. It possesses a strong bitter taste, whereas its enantiomer (-)-Lyoniresinol is odorless.
Lyoniresinol
😃Good
Catalog No. TN4469Cas No. 14464-90-5
Lyoniresinol, a lignan isolated from Tarenna attenuata, exhibits free radical scavenging activity (IC50 of 82.4 μM) and DPPH antioxidant activity, demonstrating anti-melanogenic properties. It possesses a strong bitter taste, whereas its enantiomer (-)-Lyoniresinol is odorless.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lyoniresinol, a lignan isolated from Tarenna attenuata, exhibits free radical scavenging activity (IC50 of 82.4 μM) and DPPH antioxidant activity, demonstrating anti-melanogenic properties. It possesses a strong bitter taste, whereas its enantiomer (-)-Lyoniresinol is odorless. |
| Targets&IC50 | DPPH:82.4 μM |
| In vitro | The goal of the current study was to study the effects of Lyoniresinol on cytotoxicity and melanin content in murine B16F10 melanoma cells and to delineate the underlying mechanism of tyrosinase inhibition. Lyoniresinol was purified from methanol extract of Vitex negundo root and when tested in B16F10, cells showed robust anti-melanogenic activity. It caused the downregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase steady state protein expression levels. Flow cytometry analysis of Lyoniresinol-treated cells showed that the latter activates extracellular receptor kinase (ERK) phosphorylation, which causes MITF protein degradation and suppression of tyrosinase activity. Lyoniresinol decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression. Contingent to more vigorous in vitro and in vivo experiments, Lyoniresinol can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.[2] |
| Molecular Weight | 420.45 |
| Formula | C22H28O8 |
| Cas No. | 14464-90-5 |
| Smiles | C(O)[C@@H]1[C@H](C=2C(C[C@H]1CO)=CC(OC)=C(O)C2OC)C3=CC(OC)=C(O)C(OC)=C3 |
| Relative Density. | 1.272 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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