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Product Introduction

Bioactivity

Description	(-)-Oxypeucedanin hydrate is a furanocoumarin. It has a role as a metabolite.
In vitro	Oxypeucedanin exhibited marginal toxicity on normal fibroblast cells and sensitive parental mouse lymphoma cells;?furthermore, they were less toxic on multidrug resistant lymphoma cells.? Oxypeucedanin showed moderate MDR reversing activity.?In the checkerboard assay, oxypeucedanin and heraclenin showed slight synergistic effect with doxorubicin.?These compounds might improve the cytotoxic effect of the standard chemotherapeutic drug doxorubicin.
Cell Research	Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods.Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines.The inhibition of the cancer MDR efflux pump ABCB1 was evaluated by flow cytometry (at 2 and 20 μM).A checkerboard microplate method was applied to study the interactions of furocoumarins and doxorubicin.Toxicity was studied using normal murine NIH/3T3 fibroblasts.
Alias	OXYPEUCEDANIN HYDRATE

Chemical Properties

Molecular Weight	304.29
Formula	C₁₆H₁₆O₆
Cas No.	133164-11-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (180.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2863 mL	16.4317 mL	32.8634 mL	164.3169 mL
5 mM	0.6573 mL	3.2863 mL	6.5727 mL	32.8634 mL
10 mM	0.3286 mL	1.6432 mL	3.2863 mL	16.4317 mL
20 mM	0.1643 mL	0.8216 mL	1.6432 mL	8.2158 mL
50 mM	0.0657 mL	0.3286 mL	0.6573 mL	3.2863 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6432 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

cytotoxic( ) Oxypeucedanin hydratecelltumorinhibitInhibitor()Oxypeucedanin hydrateantiproliferativecancerOxypeucedanin Hydrate