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(S)-Terazosin

Catalog No. T12815 CAS 109351-33-9

(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).

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(S)-Terazosin, CAS 109351-33-9

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Purity: 98%

Biological Description

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Description	(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).
Targets&IC50	α1a-adrenoceptor:ki： 3.91 nM , α2a-adrenoceptor: 729 nM (ki), α1b-adrenoceptor:0.79 nM (ki), α2Ba-adrenoceptor:3.5 nM (ki), α1D-adrenoceptor:1.16 nM (ki), α2C-adrenoceptor:46.4 nM (ki)
In vitro	(S)-Terazosin and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors, and showed potent α1-adrenoceptors antagonist in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate.
In vivo	(S)-Terazosin shows α2B receptor antagonist at rat atrial(pEC30 of 6.93). (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively.

Molecular Weight	387.43
Formula	C19H25N5O4
CAS No.	109351-33-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (387.17 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15(7-8):863-85.

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Keywords

(S)-Terazosin 109351-33-9 GPCR/G Protein Neuroscience Adrenergic Receptor (S) Terazosin (S)Terazosin Inhibitor inhibitor inhibit

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