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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $119 | 5 days | |
5 mg | $198 | 5 days | |
50 mg | $789 | 6-8 weeks | |
100 mg | $1,240 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $226 | 5 days |
Description | (S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively. |
Targets&IC50 | α1A-adrenoceptor:ki: 3.91 nM , α2A-adrenoceptor: 729 nM (ki), α2B-adrenoceptor:3.5 nM (ki), α1D-adrenoceptor:1.16 nM (ki), α1B-adrenoceptor:0.79 nM (ki), α2C-adrenoceptor:46.4 nM (ki) |
In vitro | (S)-Terazosin and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors, and showed potent α1-adrenoceptors antagonist in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate. |
In vivo | (S)-Terazosin shows α2B receptor antagonist at rat atrial(pEC30 of 6.93). (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively. |
Molecular Weight | 387.43 |
Formula | C19H25N5O4 |
Cas No. | 109351-33-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (387.17 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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