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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $50 | In Stock | |
1 mL x 10 mM (in DMSO) | $95 | In Stock |
Description | 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. |
In vitro | 7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1]. |
In vivo | 7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2]. |
Alias | 10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 10-Deacetylpaclitaxel 7-Xyloside |
Molecular Weight | 943.98 |
Formula | C50H57NO17 |
Cas No. | 90332-63-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (26.48 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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