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12(S)-HHT
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Catalog No. T41365Cas No. 54397-84-1
Alias 12S-HHT, 12(S)-HHTrE
12(S)-HHT (12(S)-HHTrE), a fatty acid produced via the arachidonic acid metabolic pathway of cyclooxygenase (COX), is an endogenous ligand and agonist of BLT2, and the 12(S)-HHT/BLT2 axis plays a role in the maintenance of homeostatic aspects of epithelial tissues and in inflammatory responses. 12(S)-HHT inhibits the p38 MAPK/NF-κB pathway through upregulation of MKP-1, leading to reduced IL-6 synthesis in UVB-irradiated HaCaT cells.
12(S)-HHT
😃Good
Catalog No. T41365Alias 12S-HHT, 12(S)-HHTrECas No. 54397-84-1
12(S)-HHT (12(S)-HHTrE), a fatty acid produced via the arachidonic acid metabolic pathway of cyclooxygenase (COX), is an endogenous ligand and agonist of BLT2, and the 12(S)-HHT/BLT2 axis plays a role in the maintenance of homeostatic aspects of epithelial tissues and in inflammatory responses. 12(S)-HHT inhibits the p38 MAPK/NF-κB pathway through upregulation of MKP-1, leading to reduced IL-6 synthesis in UVB-irradiated HaCaT cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $429 | 35 days | |
| 50 μg | Inquiry | 35 days | |
| 100 μg | Inquiry | 35 days | |
| 250 μg | Inquiry | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 12(S)-HHT (12(S)-HHTrE), a fatty acid produced via the arachidonic acid metabolic pathway of cyclooxygenase (COX), is an endogenous ligand and agonist of BLT2, and the 12(S)-HHT/BLT2 axis plays a role in the maintenance of homeostatic aspects of epithelial tissues and in inflammatory responses. 12(S)-HHT inhibits the p38 MAPK/NF-κB pathway through upregulation of MKP-1, leading to reduced IL-6 synthesis in UVB-irradiated HaCaT cells. |
| In vitro | Methods: HaCaT cells were treated with 12(S)-HHT (0, 12.5, 25, 75, 150 nM) and further incubated for 3 h. Total RNA was extracted from the cells, and IL-6 mRNA levels were analyzed by semi-quantitative RT-PCR. Results: 12(S)-HHT exhibited anti-inflammatory activity by attenuating UVB-induced IL-6 synthesis in HaCaT cells. [2] |
| Alias | 12S-HHT, 12(S)-HHTrE |
| Molecular Weight | 280.4 |
| Formula | C17H28O3 |
| Cas No. | 54397-84-1 |
| Smiles | [C@@H](/C=C/C=C/C/C=C\CCCC(O)=O)(CCCCC)O |
Storage & Solubility Information
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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