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24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.
Description | 24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases. |
In vitro | 24(S)-hydroxy Cholesterol (1, 10, 30 μM) was able to effectively protect the isolated rat retina from damage caused by elevated hydrostatic pressure. [1] |
Alias | Cerebrosterol, 24S-OHC, 24S-HC |
Molecular Weight | 402.65 |
Formula | C27H46O2 |
Cas No. | 474-73-7 |
Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CC[C@@H](C(C)C)O)C)[H])[H] |
Relative Density. | 1.03g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | Ethanol: 16.00 mg/mL (39.74 mM), Sonication is recommended. DMSO: 10.00 mg/mL (24.84 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol
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