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24(S)-hydroxy Cholesterol

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Catalog No. T21562Cas No. 474-73-7
Alias Cerebrosterol, 24S-OHC, 24S-HC

24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.

24(S)-hydroxy Cholesterol

24(S)-hydroxy Cholesterol

🥰Excellent
Catalog No. T21562Alias Cerebrosterol, 24S-OHC, 24S-HCCas No. 474-73-7
24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.
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Product Introduction

Bioactivity
Description
24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.
In vitro
24(S)-hydroxy Cholesterol (1, 10, 30 μM) was able to effectively protect the isolated rat retina from damage caused by elevated hydrostatic pressure. [1]
AliasCerebrosterol, 24S-OHC, 24S-HC
Chemical Properties
Molecular Weight402.65
FormulaC27H46O2
Cas No.474-73-7
SmilesC[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CC[C@@H](C(C)C)O)C)[H])[H]
Relative Density.1.03g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 16.00 mg/mL (39.74 mM), Sonication is recommended.
DMSO: 10.00 mg/mL (24.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.4835 mL12.4177 mL24.8355 mL124.1773 mL
5 mM0.4967 mL2.4835 mL4.9671 mL24.8355 mL
10 mM0.2484 mL1.2418 mL2.4835 mL12.4177 mL
20 mM0.1242 mL0.6209 mL1.2418 mL6.2089 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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