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Rel-TREM2 agonist-2

🥰Excellent
Catalog No. T62750LCas No. 2738485-99-7

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b] The EC50 value of pyrazine against TREM2 was ≤ 0.05 μM and the E.max value was > 250 μM.

Rel-TREM2 agonist-2
Other Forms of Rel-TREM2 agonist-2:
TREM2 agonist-2T627502738485-98-6
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Rel-TREM2 agonist-2

🥰Excellent
Purity: 99%
Catalog No. T62750LCas No. 2738485-99-7
rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b] The EC50 value of pyrazine against TREM2 was ≤ 0.05 μM and the E.max value was > 250 μM.
Pack SizePriceAvailabilityQuantity
1 mg$320In Stock
5 mg$779In Stock
10 mg$1,090In Stock
25 mg$1,620In Stock
50 mg$2,180In Stock
100 mg$2,930In Stock
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Purity:99%
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Product Introduction

Bioactivity
Description
rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b] The EC50 value of pyrazine against TREM2 was ≤ 0.05 μM and the E.max value was > 250 μM.
Chemical Properties
Molecular Weight451.92
FormulaC24H23ClFN5O
Cas No.2738485-99-7
SmilesCC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5
Relative Density.1.40 g/cm3 at 20℃ (Predicted)
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (121.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2128 mL11.0639 mL22.1278 mL110.6391 mL
5 mM0.4426 mL2.2128 mL4.4256 mL22.1278 mL
10 mM0.2213 mL1.1064 mL2.2128 mL11.0639 mL
20 mM0.1106 mL0.5532 mL1.1064 mL5.5320 mL
50 mM0.0443 mL0.2213 mL0.4426 mL2.2128 mL
100 mM0.0221 mL0.1106 mL0.2213 mL1.1064 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

rel5(4Chloro2fluorophenyl)2,3dimethyl7[(2R,4S)tetrahydro2(1methyl1Hpyrazol4yl)2Hpyran4yl]pyrido[3,4b]pyrazine
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