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TREM2 agonist-2
🥰Excellent
Catalog No. T62750Cas No. 2738485-98-6
TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.
TREM2 agonist-2
🥰Excellent
Purity: 100%
Catalog No. T62750Cas No. 2738485-98-6
TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $283 | In Stock | |
| 5 mg | $698 | In Stock | |
| 10 mg | $1,160 | In Stock | |
| 25 mg | $2,130 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,520 | In Stock |
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Purity:100%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research. |
| In vitro | Treatment with TREM2 agonist-2 (0-100μM; 16 hours) activated hTREM2 in HEK293 cells, with an EC50 value less than 0.05μM for cell viability assay[1]. |
| In vivo | The results indicate that TREM2 agonist-2 (50 mg/kg; twice daily; oral gavage for one day) can bind to the TREM2 target, which can interact with microglial cells[1]. |
| Molecular Weight | 451.92 |
| Formula | C24H23ClFN5O |
| Cas No. | 2738485-98-6 |
| Smiles | CC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45.19 mg/mL (100 mM）, Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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