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3',4',5',5,7-Pentamethoxyflavone

Catalog No. T2A2486 CAS 53350-26-8

Synonyms: 5,7,3',4',5'-Pentamethoxyflavone

3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits resistance to cancer cells by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

3',4',5',5,7-Pentamethoxyflavone Chemical Structure

3',4',5',5,7-Pentamethoxyflavone, CAS 53350-26-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 70.00
5 mg	In stock	$ 172.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 492.00
50 mg	In stock	$ 718.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 193.00

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Description	3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits resistance to cancer cells by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.
In vitro	3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.[1]
In vivo	The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-Pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. Plasma concentrations and area under the plasma concentration versus time curve for PMF were higher than those for tricin. A mono-O-desmethyl PMF and several isomeric mono-O-desmethyl PMF glucuronides and sulfonates were major PMF metabolites in murine plasma, liver and intestinal tissue. In murine and human liver fractions, in vitro metabolic removal of tricin was faster than that of PMF[1].

Synonyms	5,7,3',4',5'-Pentamethoxyflavone
Molecular Weight	372.37
Formula	C20H20O7
CAS No.	53350-26-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (60.4 mM), Sonification is recommended.

References and Literature

1. Hou X, et al. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015;38(5):396-401. 2. Cai H, et al. Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). Cancer Chemother Pharmacol. 2011;67(2):255-263. 3. Cai H, et al. Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection. Biomed Chromatogr. 2009;23(4):335-339.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Anti-Obesity Compound Library Anti-Cancer Compound Library Natural Product Library for HTS NF-κB Signaling Compound Library Flavonoid Natural Product Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

3',4',5',5,7-Pentamethoxyflavone 53350-26-8 Immunology/Inflammation Nrf2 3',4',5',5,7-Pentamethoxyflavone 5,7,3',4',5'-Pentamethoxyflavone inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.

3',​4',​5',​5,​7-​Pentamethoxyflavone

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3',4',5',5,7-Pentamethoxyflavone