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TOPBioactivityChemical infoStorage&SolubilityCalculator

3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

Catalog No. TN1088Cas No. 1178-24-1
Alias 3,3',4',5,6,7,8-heptamethoxyflavone

3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis.

3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

Purity: 99.69%
Catalog No. TN1088Alias 3,3',4',5,6,7,8-heptamethoxyflavoneCas No. 1178-24-1
3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis.
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$222In Stock
10 mg$328In Stock
25 mg$553In Stock
50 mg$789In Stock
100 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$253In Stock
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Purity:99.69%
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COA HNMR HPLC
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Product Introduction

Bioactivity
Description
3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis.
In vitro
3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), extracted from C. unshiu peels using ethanol extraction and hexane fractionation, inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed matrix metalloproteinases 1 (MMP-1) expression and induced type I procollagen protein expression in these cells. Additionally, HMF inhibited UVB-induced phosphorylation of MAPK cascade signaling components—ERK, JNK, and c-Jun—thereby reducing MMP-1 expression. Furthermore, HMF modulated the TGF-β/Smad signaling pathway by inducing Smad3 and suppressing Smad7 protein expressions in a dose-dependent manner in UV-induced HDFn cells.
Alias3,3',4',5,6,7,8-heptamethoxyflavone
Chemical Properties
Molecular Weight432.42
FormulaC22H24O9
Cas No.1178-24-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (27.75 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3126 mL11.5628 mL23.1257 mL115.6283 mL
5 mM0.4625 mL2.3126 mL4.6251 mL23.1257 mL
10 mM0.2313 mL1.1563 mL2.3126 mL11.5628 mL
20 mM0.1156 mL0.5781 mL1.1563 mL5.7814 mL

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Keywords

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