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6H05

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Catalog No. T1931Cas No. 1469338-01-9
Alias K-Ras inhibitor

6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).

6H05

6H05

😃Good
Catalog No. T1931Alias K-Ras inhibitorCas No. 1469338-01-9
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Pack SizePriceAvailabilityQuantity
5 mg$1294-6 weeks
10 mg$2264-6 weeks
25 mg$3744-6 weeks
50 mg$5554-6 weeks
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Product Introduction

Bioactivity
Description
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Kinase Assay
Measurement of NF-κB transcriptional activity: Macrophages RAW 264.7 transfected stably with reporter plasmid of pNF-κB-SEAP-NPT are treated with 1 μg/ml LPS and/or sample for 16 hours. As the reporter, SEAP activity in the cell-free culture media is measured as followed. Single cell-derived stable transfectants are plated in 5 ml of T-25 flask, and the media is decanted 24 h later. At this time, cells are washed twice with phosphate-buffered saline, and incubations are initiated by addition of new media. Chemicals are added to the culture medium after 24 h of incubations. Aliquots (25 ml) of medium from a control or chemical-treated cultures are taken at 0, 3, 20, 24, 48, and 72 h, heated at 65°C for 5 min to eliminate the alkaline phosphatase activity, and used immediately or stored at -20°C. Mixtures consisting of dilution buffer (25 ml), assay buffer (97 ml), culture media (25 ml), and 4-methylumbelliferyl phosphate (MUP, 1 mM, 3 ml) in each well of the 96-well plates are incubated for 60 min in the dark at room temperature. Fluorescence emits the product of the SEAP/MUP is measured at 449 nm using a 96-well plate fluorometer after excitation at 360 nm.
AliasK-Ras inhibitor
Chemical Properties
Molecular Weight476.12
FormulaC20H30ClN3O2S3
Cas No.1469338-01-9
SmilesC(CSC1=CC=C(Cl)C=C1)(=O)N2CCC(C(NCCSSCCN(C)C)=O)CC2
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1003 mL10.5016 mL21.0031 mL105.0155 mL
5 mM0.4201 mL2.1003 mL4.2006 mL21.0031 mL
10 mM0.2100 mL1.0502 mL2.1003 mL10.5016 mL

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