Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | 5 days | $ 1,090.00 |
Description | A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1]. |
Targets&IC50 | ALK7 cell-based:7.5 nM , ALK5, cell-based:12 nM , ALK4 cell-based:45 nM |
In vitro | A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, reduces the level of ALK-5-induced transcription with an IC 50 of 12 nM in Mv1Lu cells, also blocks the ALK4-TD and ALK7-TD induced transcription with IC 50 s of 45 nM and 7.5 nM in R4-2 cells, and weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 μM) potently prevents the growth-inhibitory effects of TGF-β, and completely inhibits the effect at 3 μM. A 83-01 (1-10 μM) inhibits TGF-β-induced Smad activation in HaCaT cells [1]. A 83-01 (1 μM) decreases cell motility, adhesion and invasion increased by TGF-β1 in HM-1 cells while not change cell proliferation [2]. |
In vivo | A 83-01 (50, 150 and 500 μg/mouse, i.p.) markedly improves survival of the mice without body weight or neurobehavioral appearances [2]. A 83-01 (0.5 mg/kg, i.p.) shows a significantly strong antitumor effect in mice bearing M109 cells [3]. |
Molecular Weight | 444.51 |
Formula | C25H19N5NaS+ |
CAS No. | 2828431-89-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (224.97 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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A 83-01 sodium salt 2828431-89-4 Angiogenesis Tyrosine Kinase/Adaptors ALK A 83 01 sodium salt A 8301 sodium salt A 83-01 sodium inhibitor inhibit