Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease. |
In vitro | AE0047 Hydrochloride (4e) is an antagonist of calcium[1]. AE0047 inhibits [3H]nimodipine binding to rat cardiac membrane homogenate (IC50 of 0.26 nM)[2]. AE0047 (1 μM) inhibits the high K+-evoked vascular smooth muscle contraction, and also inhibits [3H]PN200-110 binding (Ki : 40.9 nM)[3]. |
In vivo | AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure(ED30 of 1.1 mg/kg)[2].In aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP), AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine [4]. |
Molecular Weight | 723.26 |
Formula | C41H43ClN4O6 |
CAS No. | 116308-56-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AE0047 Hydrochloride 116308-56-6 Membrane transporter/Ion channel Metabolism Calcium Channel AE 0047 Hydrochloride AE-0047 Hydrochloride inhibitor inhibit