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AG-024322
🥰Excellent
Catalog No. T14136Cas No. 837364-57-5
Alias AG-024322, AG024322, AG 024322
AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).
AG-024322
🥰Excellent
Purity: 98.53%
Catalog No. T14136Alias AG-024322, AG024322, AG 024322Cas No. 837364-57-5
AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 664 € | In Stock |
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Purity:98.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM). |
| Targets&IC50 | CDK4:2.9 nM （ki）, CDK1:2.3 nM （ki）, CDK1:2.3 nM (Ki), CDK2:3 nM (Ki), CDK4:2.9 nM (Ki), HCT116 cells:120 nM, CDK2:3 nM （ki） |
| In vitro | Biotin-PEG4-Picolyl azide can utilize the ubiquitin-proteasome system to achieve selective elimination of target proteins through E3 ubiquitin ligase-mediated specific degradation of target proteins [1]. |
| In vivo | In male and female cynomolgus monkeys, AG-024322 (at doses of 2, 6, and 10 mg/kg; intravenous infusion; over 5 days) resulted in dose-dependent pancytopenic bone marrow hypocellularity and lymphoid depletion in lymph nodes, spleen, and/or thymus at doses greater than 6 mg/kg[1]. |
| Alias | AG-024322, AG024322, AG 024322 |
| Molecular Weight | 418.44 |
| Formula | C23H20F2N6 |
| Cas No. | 837364-57-5 |
| Smiles | CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(F)cc(F)c5[nH]4)c3c2)c1C |
| Relative Density. | 1.361 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (191.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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