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AMG 837
😃Good
Catalog No. T14216Cas No. 865231-46-5
Alias AMG837
AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents.
AMG 837
😃Good
Catalog No. T14216Alias AMG837Cas No. 865231-46-5
AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | 35 days | |
| 5 mg | $290 | 35 days | |
| 10 mg | $533 | 35 days | |
| 25 mg | $1,210 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents. |
| In vivo | Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. [2] |
| Alias | AMG837 |
| Molecular Weight | 438.44 |
| Formula | C26H21F3O3 |
| Cas No. | 865231-46-5 |
| Smiles | C(OC1=CC=C([C@H](CC(O)=O)C#CC)C=C1)C=2C=C(C=CC2)C3=CC=C(C(F)(F)F)C=C3 |
| Relative Density. | 1.251 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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