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AMG 837 calcium hydrate

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Purity:98.07%

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COA HPLC HNMR

AMG 837 calcium hydrate

Catalog No. TQ0020Cas No. 1259389-38-2

AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).

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Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$51	In Stock
5 mg	$80	In Stock
10 mg	$122	In Stock
25 mg	$257	In Stock
50 mg	$513	In Stock
100 mg	$729	In Stock
200 mg	$995	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description	AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
In vitro	GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50: 13 nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50s: 23/13 nM). AMG 837 was a partial agonist on GPR40 with maximal activity 85% of that shown by DHA. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50: 3 μM) on the α2-adrenergic receptor [1].
In vivo	In rats, AMG 837 increases insulin release when glucose levels are elevated [2].

Chemical Properties

Molecular Weight	950.97
Formula	C52H44CaF6O8
Cas No.	1259389-38-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (87.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0516 mL	5.2578 mL	10.5156 mL	52.5779 mL
5 mM	0.2103 mL	1.0516 mL	2.1031 mL	10.5156 mL
10 mM	0.1052 mL	0.5258 mL	1.0516 mL	5.2578 mL
20 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6289 mL
50 mM	0.0210 mL	0.1052 mL	0.2103 mL	1.0516 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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