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AR-M 1896 Acetate

Catalog No. T21646L CAS T21646L

Synonyms: AR-M 1896 Acetate (367518-31-8 Free base)

AR-M 1896 Acetate is the selective agonist of GalR2.

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AR-M 1896 Acetate, CAS T21646L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 941.00
5 mg	In stock	$ 1,880.00
10 mg	In stock	$ 2,560.00
25 mg	In stock	$ 3,780.00
50 mg	In stock	$ 5,130.00
100 mg	In stock	$ 6,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 3,910.00

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Purity: 95.32%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AR-M 1896 Acetate is the selective agonist of GalR2.
Targets&IC50	GalR2:1.76 nM, GalR1 (human):879 Nm
In vitro	Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs[1].?
In vivo	In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats[1].

Synonyms	AR-M 1896 Acetate (367518-31-8 Free base)
Molecular Weight	1196.35
Formula	C56H85N13O16
CAS No.	T21646L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (45.97 mM)

References and Literature

1. Liu HX, Brumovsky P, Schmidt R, Brown W, Payza K, Hodzic L, Pou C, Godbout C, H?kfelt T. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9960-4

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Pancreatic Polypeptide (human) acetate [D-Trp34]-Neuropeptide Y Acetate Ala5-Galanin (2-11) L 152804 Neurokinin antagonist 1 M871 acetate HT-2157 Galanin-Like Peptide (porcine)

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Keywords

AR-M 1896 Acetate T21646L GPCR/G Protein Neuroscience Neuropeptide Y Receptor 367518-31-8 Free base ARM 1896 Acetate AR M 1896 Acetate AR-M-1896 Acetate 367518-31-8 AR-M 1896 Acetate (367518-31-8 Free base) AR-M1896 Acetate inhibitor inhibit

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