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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $149 | In Stock |
Description | AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer. |
Targets&IC50 | ACK1:156 nM, FLT3:302 nM, FES:449 nM, MNK2:228 nM, MLK1:88 nM, ALK:420 nM, IGF-1R:1.6 μM, ERB4:195 nM, BRK:843 nM, IRR:840 nM |
In vitro | AZ7550 trimesylate salt (Compound 28) demonstrates a potency and selectivity profile broadly similar to the parent compound AZD9291. Inhibiting the double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild-type (WT) cell line LoVo, AZ7550 trimesylate salt exhibits IC50s of 45, 26, and 786 nM, respectively. Moreover, it inhibits the antiproliferative cell lines H1975 (DM), PC9 (AM), and Calu3 (WT) with GI50s of 19, 15, and 537 nM, respectively[1]. |
Alias | AZ7550 Mesylate, AZ7550 trimesylate salt (1421373-99-0 free base) |
Molecular Weight | 773.9 |
Formula | C30H43N7O11S3 |
Cas No. | 2319837-99-3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (25.84 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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