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AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $126 | In Stock | |
5 mg | $257 | In Stock | |
10 mg | $397 | In Stock | |
25 mg | $663 | In Stock | |
50 mg | $945 | In Stock |
Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
Targets&IC50 | ERB4:195 nM , IGF-1R:1.6 μM , FLT4:1784 nM , MNK2:228 nM , ALK:420 nM , Brk:843 nM , MLK1:88 nM , BLK:977 nM , INSR:1256 nM , PYK2:2288 nM , Ack1:156 nM , FLT3:302 nM , FAK:995 nM , FES:449 nM , TEC:1317 nM , IRR:840 nM |
In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
Alias | AZ7550 hydrochloride (1421373-99-0 free base) |
Molecular Weight | 522.04 |
Formula | C27H32ClN7O2 |
Cas No. | 2309762-40-9 |
Smiles | C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2)=C(C=C1N(CCNC)C)OC)=O.[H]Cl |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | DMSO: 1.5 mg/mL (2.8 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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