BMS-935177

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

Catalog No. T14681Cas No. 1231889-53-4

Select Batch

Purity:99.89%

Resource Download

COA HPLC HNMR

BMS-935177

Catalog No. T14681Cas No. 1231889-53-4

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$62	In Stock
10 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$170	In Stock

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
Targets&IC50	BTK:3 nM
In vitro	In human Ramos B cells, BMS-935177 inhibits calcium flux with an IC50 of 27 nM. BMS-935177 inhibits CD69 surface expression in peripheral B cells stimulated with antiIgM and anti-IgG. Against IgG-containing immune complexdriven low affinity activating FcγRIIa and FcγRIII end points in peripheral blood mononuclear cells, BMS-935177 effectively inhibits TNFα production (IC50 = 14 nM). BMS-935177 shows mean IC50 values of 550 and 2060 nM in human and mouse whole blood, respectively[1].
In vivo	BMS-935177(5, 20, and 45 mg/kg) inhibits anti-KLH antibodies of the IgG isotype at day 14, with statistically significant reductions at all doses. In satellite mice, BMS-935177 (5 mg/kg) maintains the plasma concentration above the mouse whole blood BCR-stimulated CD69 IC50 value of 2 μM for only 5 h. BMS-935177(10, 20, and 30 mg/kg) provides dose-dependently reduces both the severity and incidence of clinically evident disease in this rodent model of RA. BMS-935177(10 mg/kg) reduces the disease severity about 40%, and the percentage of animals showing any signs of disease is reduced by a third[1].

Chemical Properties

Molecular Weight	502.56
Formula	C₃₁H₂₆N₄O₃
Cas No.	1231889-53-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 117 mg/mL (232.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9898 mL	9.9491 mL	19.8981 mL	99.4906 mL
5 mM	0.3980 mL	1.9898 mL	3.9796 mL	19.8981 mL
10 mM	0.1990 mL	0.9949 mL	1.9898 mL	9.9491 mL
20 mM	0.0995 mL	0.4975 mL	0.9949 mL	4.9745 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9898 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9949 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc