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BOS-318

BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.

Catalog No. T9964Cas No. 2387633-15-8

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Purity:99.06%

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COA HPLC HNMR

BOS-318

Catalog No. T9964Cas No. 2387633-15-8

BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$159	In Stock
25 mg	$322	In Stock
50 mg	$513	In Stock
100 mg	$747	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Product Introduction

Bioactivity

Description

BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.

In vitro

BOS-318 (0.001-1 μM) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA). BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent that PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM). BOS-318 (0.3 μM, 2h or 48 h)reduces ENaC-mediated Na+ absorption in CF HBECs and protects aganist NE- and CF sputum-sol-mediated activation of ENaC. [1]

Chemical Properties

Molecular Weight	571.5
Formula	C₂₈H₃₂Cl₂N₆O₃
Cas No.	2387633-15-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 12.5 mg/mL (21.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7498 mL	8.7489 mL	17.4978 mL	87.4891 mL
5 mM	0.3500 mL	1.7498 mL	3.4996 mL	17.4978 mL
10 mM	0.1750 mL	0.8749 mL	1.7498 mL	8.7489 mL
20 mM	0.0875 mL	0.4374 mL	0.8749 mL	4.3745 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FurinInhibitorENaCneutrophil elastaseinhibitBOS318BOS 318BOS-318