Boc-Val-Cit-PAB-PNP

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Catalog No. T17692Cas No. 870487-10-8

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Purity:97.9%

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COA HPLC HNMR

Boc-Val-Cit-PAB-PNP

Catalog No. T17692Cas No. 870487-10-8

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$51	In Stock
25 mg	$79	In Stock
50 mg	$108	In Stock
100 mg	$158	In Stock
500 mg	$392	In Stock

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Product Introduction

Bioactivity

Description	Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro	ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Chemical Properties

Molecular Weight	644.67
Formula	C₃₀H₄₀N₆O₁₀
Cas No.	870487-10-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5512 mL	7.7559 mL	15.5118 mL	77.5591 mL
5 mM	0.3102 mL	1.5512 mL	3.1024 mL	15.5118 mL
10 mM	0.1551 mL	0.7756 mL	1.5512 mL	7.7559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc