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CAL-130 Hydrochloride

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CAL-130 Hydrochloride

Catalog No. T10660LCas No. 1431697-78-7

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).

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Pack Size	Price	Availability
2 mg	$127	5 days
5 mg	$249	5 days
25 mg	$763	6-8 weeks
50 mg	$992	6-8 weeks
100 mg	$1,490	6-8 weeks
1 mL x 10 mM (in DMSO)	$287	5 days

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Product Introduction

Bioactivity

Description	CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Targets&IC50	p110γ:6.1 nM, p110δ:1.3 nM, p110α:115 nM, p110β:56 nM
In vitro	CAL-130 selectively inhibits the catalytic domains of p110γ and p110δ with IC50s of 1.3 and 6.1 nM, respectively (115 and 56 nM for p110α and p110β), and does not affect other intracellular signaling pathways essential for cell function and survival, such as p38 MAPK or insulin receptor tyrosine kinase.
In vivo	The clinical significance of inhibiting PI3Kγ and PI3Kδ activities is assessed by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia. Candidate mice, exhibiting illness, a white blood cell count above 45,000/μL, blasts on peripheral smear, and >75% Thy1.2 and Ki-67 double-positive circulating cells, receive an oral dose (10 mg/kg) of CAL-130 every 8 hours for 7 days and are monitored until moribund. Despite the limited duration of therapy, CAL-130 effectively extends median survival to 45 days compared to 7.5 days for the control group.

Chemical Properties

Molecular Weight	462.94
Formula	C23H23ClN8O
Cas No.	1431697-78-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (108.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1601 mL	10.8005 mL	21.6011 mL	108.0054 mL
5 mM	0.4320 mL	2.1601 mL	4.3202 mL	21.6011 mL
10 mM	0.2160 mL	1.0801 mL	2.1601 mL	10.8005 mL
20 mM	0.1080 mL	0.5400 mL	1.0801 mL	5.4003 mL
50 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
100 mM	0.0216 mL	0.1080 mL	0.2160 mL	1.0801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc