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CAL-130 Hydrochloride

Catalog No. T10660LCas No. 1431697-78-7

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).

CAL-130 Hydrochloride

CAL-130 Hydrochloride

Catalog No. T10660LCas No. 1431697-78-7
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Pack SizePriceAvailabilityQuantity
2 mg$1275 days
5 mg$2495 days
25 mg$7636-8 weeks
50 mg$9926-8 weeks
100 mg$1,4906-8 weeks
1 mL x 10 mM (in DMSO)$2875 days
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Product Introduction

Bioactivity
Description
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Targets&IC50
p110β:56 nM, p110α:115 nM, p110γ:6.1 nM, p110δ:1.3 nM
In vitro
CAL-130 selectively inhibits the catalytic domains of p110γ and p110δ with IC50s of 1.3 and 6.1 nM, respectively (115 and 56 nM for p110α and p110β), and does not affect other intracellular signaling pathways essential for cell function and survival, such as p38 MAPK or insulin receptor tyrosine kinase.
In vivo
The clinical significance of inhibiting PI3Kγ and PI3Kδ activities is assessed by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia. Candidate mice, exhibiting illness, a white blood cell count above 45,000/μL, blasts on peripheral smear, and >75% Thy1.2 and Ki-67 double-positive circulating cells, receive an oral dose (10 mg/kg) of CAL-130 every 8 hours for 7 days and are monitored until moribund. Despite the limited duration of therapy, CAL-130 effectively extends median survival to 45 days compared to 7.5 days for the control group.
Chemical Properties
Molecular Weight462.94
FormulaC23H23ClN8O
Cas No.1431697-78-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (108.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1601 mL10.8005 mL21.6011 mL108.0054 mL
5 mM0.4320 mL2.1601 mL4.3202 mL21.6011 mL
10 mM0.2160 mL1.0801 mL2.1601 mL10.8005 mL
20 mM0.1080 mL0.5400 mL1.0801 mL5.4003 mL
50 mM0.0432 mL0.2160 mL0.4320 mL2.1601 mL
100 mM0.0216 mL0.1080 mL0.2160 mL1.0801 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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