Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 127.00 | |
5 mg | 5 days | $ 249.00 | |
25 mg | 6-8 weeks | $ 763.00 | |
50 mg | 6-8 weeks | $ 992.00 | |
100 mg | 6-8 weeks | $ 1,490.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 287.00 |
Description | CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM). |
Targets&IC50 | p110α:115 nM, p110γ:6.1 nM, p110δ:1.3 nM, p110β:56 nM |
In vitro | CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains (IC50s: 1.3 and 6.1 nM for p110δ and p110γ, 115 and 56 nM for p110α and p110β). CAL-130 does not inhibit additional intracellular signaling pathways (i.e., p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival. |
In vivo | The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia. Candidate animals for survival studies are ill-appearing, have a white blood cell count above 45,000/μL, evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double-positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared to 7.5 days for the control group. |
Molecular Weight | 462.94 |
Formula | C23H23ClN8O |
CAS No. | 1431697-78-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (108.01 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CAL-130 Hydrochloride 1431697-78-7 PI3K/Akt/mTOR signaling PI3K CAL 130 Hydrochloride CAL130 Hydrochloride inhibitor inhibit