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CGP 78608 hydrochloride

Catalog No. T10781 CAS 1135278-54-4

Synonyms: PAMQX

CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).

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CGP 78608 hydrochloride Chemical Structure

CGP 78608 hydrochloride, CAS 1135278-54-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 243.00
25 mg	In stock	$ 535.00
50 mg	In stock	$ 773.00
100 mg	In stock	$ 1,080.00

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Purity: 99.68%

Purity: 98.96%

ee: 100%

Biological Description

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Storage & Solubility Information

Description	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
Targets&IC50	NMDAR:6 nM
In vitro	CGP 78608 hydrochloride reduces ammonia-dependent cGMP synthesis and relieves ammonia neurotoxicity[2]. CGP-78608 hydrochloride reduces glycine sensitivity of GluN1 and GluN3A receptors[3].
In vivo	CGP-78608 (i.p.) exhibits anticonvulsant effects in the electroshock-induced convulsions assay in mice[1].

Synonyms	PAMQX
Molecular Weight	414.58
Formula	C11H14BrClN3O5P
CAS No.	1135278-54-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37.4 mg/mL (90.0 mM)

References and Literature

1. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. 2. Hilgier W, et al. A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. Brain Res. 2004 Jul 23;1015(1-2):186-8. 3. Grand T, et al. Unmasking GluN1/GluN3A excitatory glycine NMDA receptors. Nat Commun. 2018 Nov 13;9(1):4769.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

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Keywords

CGP 78608 hydrochloride 1135278-54-4 Membrane transporter/Ion channel Neuroscience NMDAR iGluR CGP78608 Hydrochloride CGP 78608 Hydrochloride PAMQX CGP-78608 Hydrochloride inhibitor inhibit

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