Shopping Cart

Remove All

Your shopping cart is currently empty

CGP 78608 hydrochloride

Select Batch

Purity:99.68%

ee:100%

Resource Download

COA HPLC HNMR LCMS CSFC

CGP 78608 hydrochloride

Catalog No. T10781Cas No. 1135278-54-4

CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$87	In Stock
5 mg	$197	In Stock
10 mg	$243	In Stock
25 mg	$535	In Stock
50 mg	$773	In Stock
100 mg	$1,080	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "CGP 78608 hydrochloride"

Product Introduction

Bioactivity

Description	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
In vitro	CGP 78608 hydrochloride reduces ammonia-dependent cGMP synthesis and relieves ammonia neurotoxicity[2]. CGP-78608 hydrochloride reduces glycine sensitivity of GluN1 and GluN3A receptors[3].
In vivo	CGP-78608 (i.p.) exhibits anticonvulsant effects in the electroshock-induced convulsions assay in mice[1].
Alias	PAMQX

Chemical Properties

Molecular Weight	414.58
Formula	C11H14BrClN3O5P
Cas No.	1135278-54-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37.4 mg/mL (90.0 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4121 mL	12.0604 mL	24.1208 mL	120.6040 mL
5 mM	0.4824 mL	2.4121 mL	4.8242 mL	24.1208 mL
10 mM	0.2412 mL	1.2060 mL	2.4121 mL	12.0604 mL
20 mM	0.1206 mL	0.6030 mL	1.2060 mL	6.0302 mL
50 mM	0.0482 mL	0.2412 mL	0.4824 mL	2.4121 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc