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Indantadol HCl

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Purity:98.24%

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COA HPLC HNMR

Indantadol HCl

Catalog No. T27606Cas No. 202914-18-9

Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.

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Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$430	In Stock
10 mg	$636	In Stock
25 mg	$987	In Stock
50 mg	$1,360	In Stock
100 mg	$1,830	In Stock
500 mg	$3,680	In Stock

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Product Introduction

Bioactivity

Description	Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
In vivo	In a human heat-capsaicin-induced pain model, Indantadol HCl at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol HCl undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of Indantadol HCl at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists. Most side effects have been observed to be mild, and include dizziness and asthenia. Indantadol HCl is currently in phase II clinical trials in patients with diabetic peripheral neuropathic pain.[1]
Alias	CHF-3381, CMP-3381, GT-3381, V-3381, CNP-3381, Indantadol

Chemical Properties

Molecular Weight	226.7
Formula	C11H15ClN2O
Cas No.	202914-18-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (220.56 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4111 mL	22.0556 mL	44.1112 mL	220.5558 mL
5 mM	0.8822 mL	4.4111 mL	8.8222 mL	44.1112 mL
10 mM	0.4411 mL	2.2056 mL	4.4111 mL	22.0556 mL
20 mM	0.2206 mL	1.1028 mL	2.2056 mL	11.0278 mL
50 mM	0.0882 mL	0.4411 mL	0.8822 mL	4.4111 mL
100 mM	0.0441 mL	0.2206 mL	0.4411 mL	2.2056 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc