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Centrinone-B

Catalog No. T14926 CAS 1798871-31-4

Synonyms: LCR-323

Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).

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Centrinone-B, CAS 1798871-31-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 689.00
50 mg	6-8 weeks	$ 896.00
100 mg	6-8 weeks	$ 1,340.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).
Targets&IC50	Aurora A:1239 nM （ki）, Aurora B:5597.14 nM （ki）, PLK4 (G95L):497.53 nM （ki）, PLK4:0.59 nM （ki）
In vitro	Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2].

Synonyms	LCR-323
Molecular Weight	631.67
Formula	C27H27F2N7O5S2
CAS No.	1798871-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (39.58 mM), Sonification is recommended.

References and Literature

1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60. 2. Denu RA, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Jan 12.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Centrinone-B 1798871-31-4 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase LCR-323 Centrinone B LCR323 LCR 323 CentrinoneB inhibitor inhibit

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