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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $689 | 6-8 weeks | |
50 mg | $896 | 6-8 weeks | |
100 mg | $1,340 | 6-8 weeks |
Description | Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM). |
In vitro | Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2]. |
Alias | LCR-323 |
Molecular Weight | 631.67 |
Formula | C27H27F2N7O5S2 |
Cas No. | 1798871-31-4 |
Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (39.58 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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