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Centrinone-B

Catalog No. T14926 CAS 1798871-31-4

Synonyms: LCR-323

Purity 98.00% Datasheet

Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).

Centrinone-B, CAS 1798871-31-4

Pack Size	Availability	Price/USD
2 mg	inquiry	98.00
5 mg	inquiry	146.00
10 mg	inquiry	239.00
50 mg	inquiry	971.00
100 mg	inquiry	inquiry
200 mg	inquiry	inquiry
1 mL * 10 mM (in DMSO)	inquiry	201.00

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Purity 98.00%

Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).
Targets&IC50	PLK4 :ic50 0.59 nM （ki）, PLK4 G95L :ic50 497.53 nM （ki）, Aurora A :ic50 1239 nM （ki）, Aurora B :ic50 5597.14 nM （ki）,
In vitro	Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2].

Synonyms	LCR-323
Purity	98.00%
Molecular Weight	631.67
Formula	C27H27F2N7O5S2
CAS No.	1798871-31-4

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 25 mg/mL (39.58 mM), Need ultrasonic

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60. 2. Denu RA, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Jan 12.

Related Products

Related compounds with same targets

SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.